Zolpidem

zolpidem

What is zolpidem?

What is zolpidem? Zolpidem is a sedative, also called a hypnotic. It affects chemicals in the brain that may be unbalanced in people with sleep problems (insomnia). Zolpidem is used to treat insomnia.

Does zolpidem have any CNS depressant effects?

Both Zolpidem and Benperidol can have CNS depressant effects, which might affect the ability to perform skilled tasks (see Drugs and Driving in Guidance on Prescribing ). Both Zolpidem and Brimonidine can have CNS depressant effects, which might affect the ability to perform skilled tasks (see Drugs and Driving in Guidance on Prescribing ).

What are the excipients in zolpidem tartrate?

Qualitative and quantitative composition Each tablet contains 5 mg zolpidem tartrate. Excipients with known effect: lactose monohydrate. Each tablet contains 45.2mg lactose monohydrate For the full list of excipients, see section 6.1.

How many milligrams of zolpidem are in a tablet?

Each tablet contains 5 mg zolpidem tartrate. Excipients with known effect: lactose monohydrate. Each tablet contains 45.2mg lactose monohydrate For the full list of excipients, see section 6.1. 3. Pharmaceutical form Film-coated tablet. Round, white to off-white, film-coated tablets. 4. Clinical particulars

What is zolpidem used for?

Zolpidem is a sleeping pill. Its used to treat insomnia (when you might have trouble getting to sleep and staying asleep). It helps you fall asleep more quickly and makes you less likely to wake up during the night. Zolpidem comes as tablets.

Is zolpidem a benzodiazepine?

Zolpidem is a nonbenzodiazepine Z drug which acts as a sedative and hypnotic. Zolpidem is a GABA A receptor agonist of the imidazopyridine class. It works by increasing GABA effects in the central nervous system by binding to GABA A receptors at the same location as benzodiazepines. It generally has a half-life of two to three hours.

What is the structure of zolpidem?

Zolpidem is an imidazo [1,2-a]pyridine compound having a 4-tolyl group at the 2-position, an N,N-dimethylcarbamoylmethyl group at the 3-position and a methyl substituent at the 6-position. It has a role as a central nervous system depressant, a GABA agonist and a sedative.

What is the half life of zolpidem?

Zolpidem is a GABA A receptor agonist of the imidazopyridine class. It works by increasing GABA effects in the central nervous system by binding to GABA A receptors at the same location as benzodiazepines. It generally has a half-life of two to three hours.

Zolpidem should only be used short term (usually up to 4 weeks) for sleep problems. This is because your body can become dependent on it. See a doctor if you feel you need to take it for longer than 4 weeks. They will be able to discuss your sleep problems and recommend other things that may help. What will happen when I stop taking it?

How many mg of zolpidem tartrate are in a tablet?

Each tablet contains 10 mg zolpidem tartrate. Excipients with known effect: lactose monohydrate. Each tablet contains 90.4mg lactose monohydrate For the full list of excipients, see section 6.1. 3. Pharmaceutical form

What are the contraindications for zolpidem tartrate?

• Zolpidem tartrate is contraindicated in patients with a hypersensitivity to zolpidem tartrate or any of the excipients listed in section 6.1. • Obstructive sleep apnoea.

How does zolpidem tartrate preserve deep sleep?

The preservation of deep sleep (stages 3 and 4 - slow-wave sleep) may be explained by the selective omega-1 binding by zolpidem tartrate. All identified effects of zolpidem tartrate are reversed by the benzodiazepine antagonist flumazenil. The randomized trials only showed convincing evidence of efficacy of 10mg zolpidem tartrate.

What is the difference between zolpidem 10 and 5 mg?

In a randomized double-blind trial in 114 non-elderly patients with chronic insomnia, zolpidem 10 mg decreased the mean time to fall asleep by 30 minutes compared to placebo, while for 5 mg zolpidem this was 15 minutes. In some patients, a lower dose of 5 mg could be effective.

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